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Article

Fabrication of a novel 3D-printed perfusion bioreactor for complex cell culture models

24 Mar 2025

Abstract excerpt

We introduce a novel fabrication method for developing a 3D-printed perfusion bioreactor (3D-PBR) to facilitate the in situ growth and differentiation of human bone marrow (BM)-derived mesenchymal stem cells (MSCs) while enabling coculture with vascular cells. To recapitulate human physiology, in vitro platforms must incorporate several key features of their native target organ. This often entails a supportive 3D...

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PMID: 40128619
DOI: 10.1038/s41598-025-94093-z

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