Article
Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance.
Scientific reports - 15 Mar 2018
Zhang Jiantao, Hu Yanmei, Foley Christopher, Wang Yuanxiang, Musharrafieh Rami, Xu Shuting, Zhang Yongtao, Ma Chunlong, Hulme Christopher, Wang Jun
Abstract excerpt
Influenza viruses are respiratory pathogens that are responsible for seasonal influenza and sporadic influenza pandemic. The therapeutic efficacy of current influenza vaccines and small molecule antiviral drugs is limited due to the emergence of multidrug-resistant influenza viruses. In response to the urgent need for the next generation of influenza antivirals, we utilized a fast-track drug discovery platform by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.