Article
Aberrant expression of MICO1 and MICO1OS in deceased somatic cell nuclear transfer calves.
Molecular reproduction and development - 1 Jun 2017
Wang Guan-Nan, Yang Wen-Zhi, Xu Da, Li Dong-Jie, Zhang Cui, Chen Wei-Na, Li Shi-Jie
Abstract excerpt
Incomplete reprogramming of a donor nucleus following somatic cell nuclear transfer (SCNT) results in aberrant expression of developmentally important genes, and is the primary source of the phenotypic abnormalities observed in cloned animals. Expression of non-coding RNAs in the murine Dlk1-Dio3 imprinted domain was previously shown to correlate with the pluripotency of mouse induced pluripotent stem cells. In...
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