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Article

RNA sequencing-based identification of aberrant imprinting in cloned mice

8 Oct 2013

Abstract excerpt

Animals cloned by somatic cell nuclear transfer (SCNT) provide a unique model for understanding the mechanisms of nuclear epigenetic reprogramming to a state of totipotency. Though many phenotypic abnormalities have been demonstrated in cloned animals, the underlying mechanisms are not well understood. In this study, we performed transcriptome-wide allelic expression analyses in brain and placental tissues of...

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PMID: 24105465
DOI: 10.1093/hmg/ddt495

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