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Dual inhibiting OCT4 and AKT potently suppresses the propagation of human cancer cells

6 Apr 2017

Abstract excerpt

AKT serves as an epigenetic modulator that links epigenetic regulation to cell survival and proliferation while the epigenetic mediator OCT4 critically controls stem cell pluripotency and self-renewal. Emerging evidence indicated their complicated interplays in cancer cells and cancer stem cells (CSCs), and inhibiting either one may activate the other. Thus, in this study, we propose a strategy to targeting both...

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PMID: 28383051
DOI: 10.1038/srep46246

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