Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4–AKT–ATP‐binding cassette G2 pathway†

26 Mar 2010

Abstract excerpt

UNLABELLED: Chemoresistance presents a major obstacle to the efficacy of chemotherapeutic treatment of cancers. Using chemotherapeutic drugs to select drug-resistant cancer cells in hepatocellular carcinoma (HCC) and several other cancer cell lines, we demonstrate that chemoresistant cells displayed cancer stem cell features, such as increased self-renewal ability, cell motility, multiple drug resistance, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cell death mechanisms and regulation
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20683952
DOI: 10.1002/hep.23692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4–AKT–ATP‐binding cassette G2 pathway†PMID 20683952Read ↗

Oct-3/4 modulates the drug-resistant phenotype of glioblastoma cells through expression of ATP binding cassette transporter G2.Semantic proximity Read ↗

Reduced tumorigenicity and drug resistance through the downregulation of octamer-binding protein 4 and Nanog transcriptional factor expression in human breast stem cells.Semantic proximity Read ↗

Octamer 4 Small Interfering RNA Results in Cancer Stem Cell–Like Cell ApoptosisSemantic proximity Read ↗

DRD4 promotes chemo-resistance and cancer stem cell-like phenotypes by mediating the activation of the Akt/β-catenin signaling axis in liver cancer.Semantic proximity Read ↗

Oct4 Gene Expression in Primary Colorectal Cancer Promotes Liver MetastasisSemantic proximity Read ↗

Oct4 induces EMT through LEF1/β-catenin dependent WNT signaling pathway in hepatocellular carcinomaSemantic proximity Read ↗

Dual inhibiting OCT4 and AKT potently suppresses the propagation of human cancer cellsSemantic proximity Read ↗

Constitutive expression of Wnt/β-catenin target genes promotes proliferation and invasion of liver cancer stem cellsSemantic proximity Read ↗

Suppression of NANOG Expression Reduces Drug Resistance of Cancer Stem Cells in GlioblastomaSemantic proximity Read ↗

Cancer cells acquire a drug resistant, highly tumorigenic, cancer stem-like phenotype through modulation of the PI3K/Akt/β-catenin/CBP pathway.Semantic proximity Read ↗

Loss of 5-hydroxymethylcytosine induces chemotherapy resistance in hepatocellular carcinoma via the 5-hmC/PCAF/AKT axisSemantic proximity Read ↗

Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.