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Article

Expression of Neuroendocrine Factor VGF in Lung Cancer Cells Confers Resistance to EGFR Kinase Inhibitors and Triggers Epithelial-to-Mesenchymal Transition.

Cancer research - 1 Jun 2017

Hwang Wen, Chiu Yu-Fan, Kuo Ming-Han, Lee Kuan-Lin, Lee An-Chun, Yu Chia-Cherng, Chang Junn-Liang, Huang Wen-Chien, Hsiao Shih-Hsin, Lin Sey-En, Chou Yu-Ting

Abstract excerpt

Mutations in EGFR drive tumor growth but render tumor cells sensitive to treatment with EGFR tyrosine kinase inhibitors (TKI). Phenotypic alteration in epithelial-to-mesenchymal transition (EMT) has been linked to the TKI resistance in lung adenocarcinoma. However, the mechanism underlying this resistance remains unclear. Here we report that high expression of a neuroendocrine factor termed VGF induces the...

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Source

Identifiers

PMID: 28381546
DOI: 10.1158/0008-5472.CAN-16-3168

Genes

VGF
EGFR
TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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