Article
Altered phenotype and functionality of varicella zoster virus-specific cellular immunity in individuals with active infection.
The Journal of infectious diseases - 15 Feb 2015
Schub David, Janssen Eva, Leyking Sarah, Sester Urban, Assmann Gunter, Hennes Pia, Smola Sigrun, Vogt Thomas, Rohrer Tilman, Sester Martina, Schmidt Tina
Abstract excerpt
BACKGROUND: Varicella zoster virus (VZV) establishes lifelong persistence and may reactivate in individuals with impaired immune function. To investigate immunologic correlates of protection and VZV reactivation, we characterized specific immunity in 207 nonsymptomatic immunocompetent and 132 immunocompromised individuals in comparison with patients with acute herpes zoster. METHODS: VZV-specific CD4 T cells were...
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