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Article

Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers.

Carcinogenesis - 1 May 2017

Ding Jiefeng, Kuo Mei-Ling, Su Leila, Xue Lijun, Luh Frank, Zhang Hang, Wang Jianghai, Lin Tiffany G, Zhang Keqiang, Chu Peiguo, Zheng Shu, Liu Xiyong, Yen Yun

Abstract excerpt

Human mitochondrial pyrroline-5-carboxylate reductase (PYCR) is a house-keeping enzyme that catalyzes the reduction of Δ1-pyrroline-5-carboxylate to proline. This enzymatic cycle plays pivotal roles in amino acid metabolism, intracellular redox potential and mitochondrial integrity. Here, we hypothesize that PYCR1 might be a novel prognostic biomarker and therapeutic target for breast cancer. In this study,...

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Source

Identifiers

PMID: 28379297
DOI: 10.1093/carcin/bgx022

Genes

PYCR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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