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Article

PYCR1 modulates ferroptosis and malignant phenotypes of clear cell renal cell carcinoma through proline biosynthesis.

Molecular biology reports - 23 Jun 2026

Zhou Jizhe, Zhou Yuting, Li Haifeng, Jiang Minlin, Guo Yueyue, Xie Delong, Yi Sangui, Liu Zongling

Abstract excerpt

BACKGROUND: Pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme in proline biosynthesis, has been implicated in various cancers. However, its role in clear cell renal cell carcinoma (ccRCC) remains elusive. METHODS: We analyzed PYCR1 expression and its correlation with clinicopathological features using the UALCAN platform based on TCGA data. Functional roles of PYCR1 in cell proliferation and migration...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

Identifiers

PMID: 42334666
DOI: 10.1007/s11033-026-12157-3

Genes

PYCR1
CCK
GPX4
SLC7A11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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