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PYCR1 promotes liver cancer cell growth and metastasis by regulating IRS1 expression through lactylation modification

1 Oct 2024

Abstract excerpt

BACKGROUND: Liver cancer (LC) is among the deadliest cancers worldwide, with existing treatments showing limited efficacy. This study aimed to elucidate the role and underlying mechanisms of pyrroline-5-carboxylate reductase 1 (PYCR1) as a potential therapeutic target in LC. METHODS: Immunohistochemistry and Western blot were used to analyse the expression of PYCR1 in LC cells and tissues. EdU assays,...

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PMID: 39422696
DOI: 10.1002/ctm2.70045

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