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Deciphering the effects of PYCR1 on cell function and its associated mechanism in hepatocellular carcinoma

1 Jan 2021

Abstract excerpt

Overexpression of pyrroline-5-carboxylate reductase 1 (PYCR1) has been associated with the development of certain cancers; however, no studies have specifically examined the role of PYCR1 in hepatocellular carcinoma (HCC). Based on The Cancer Genome Atlas expression array and meta-analysis conducted using the Gene Expression Omnibus database, we determined that PYCR1 was upregulated in HCC compared to adjacent...

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PMID: 34239351
DOI: 10.7150/ijbs.58026

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