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Article

Computationally Discovered Potentiating Role of Glycans on NMDA Receptors.

Scientific reports - 5 Apr 2017

Sinitskiy Anton V, Stanley Nathaniel H, Hackos David H, Hanson Jesse E, Sellers Benjamin D, Pande Vijay S

Abstract excerpt

N-methyl-D-aspartate receptors (NMDARs) are glycoproteins in the brain central to learning and memory. The effects of glycosylation on the structure and dynamics of NMDARs are largely unknown. In this work, we use extensive molecular dynamics simulations of GluN1 and GluN2B ligand binding domains (LBDs) of NMDARs to investigate these effects. Our simulations predict that intra-domain interactions involving the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28378791
DOI: 10.1038/srep44578
PMCID: PMC5381272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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