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Article

Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody.

Scientific reports - 3 Apr 2017

Rizk Shahir S, Mukherjee Somnath, Koide Akiko, Koide Shohei, Kossiakoff Anthony A

Abstract excerpt

We have utilized a high-diversity phage display library to engineer antibody fragments (Fabs) that can modulate the activity of the enzyme isocitrate dehydrogenase 1 (IDH1). We show that a conformation-specific Fab can reactivate an IDH1 mutant associated with brain tumors. The results show that this strategy is a first step towards developing "activator drugs" for a large number of genetic disorders where...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28373671
DOI: 10.1038/s41598-017-00728-1
PMCID: PMC5429742

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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