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Article

A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity.

The Journal of biological chemistry - 22 Sept 2017

Banerjee Victor, Oren Ofek, Ben-Zeev Efrat, Taube Ran, Engel Stanislav, Papo Niv

Abstract excerpt

Molecular agents that specifically bind and neutralize misfolded and toxic superoxide dismutase 1 (SOD1) mutant proteins may find application in attenuating the disease progression of familial amyotrophic lateral sclerosis. However, high structural similarities between the wild-type and mutant SOD1 proteins limit the utility of this approach. Here we addressed this challenge by converting a promiscuous natural...

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Source

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Identifiers

PMID: 28768772
DOI: 10.1074/jbc.M117.789610
PMCID: PMC5612109

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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