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Article

Engineering non-natural inhibitor sensitivity in protein tyrosine phosphatase H1.

Bioorganic & medicinal chemistry - 15 Jan 2006

Blair Elizabeth R, Hoffman Hillary E, Bishop Anthony C

Abstract excerpt

Protein tyrosine phosphatase H1, a member of the ubiquitous protein tyrosine phosphatase (PTP) superfamily of enzymes, is an important signaling molecule, mutant forms of which have been found in human colorectal cancers. Selective PTPH1 inhibitors would be valuable tools for investigating PTPH1's roles in cellular regulation. However, no PTPH1-specific inhibitors are known. To identify target-selective...

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Identifiers

PMID: 16182535
DOI: 10.1016/j.bmc.2005.08.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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