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Article

Biostructural, biochemical and biophysical studies of mutant IDH1.

Nature communications - 9 Sept 2024

McCoy Mark A, Lu Jun, Richard Miller F, Soisson Stephen M, Lam Michael H, Fischer Christian

Abstract excerpt

We report bio-structural, bio-chemical and bio-physical evidence demonstrating how small molecules can bind to both wild-type and mutant IDH1, but only inhibit the enzymatic activity of the mutant isoform. Enabled through x-ray crystallography, we characterized a series of small molecule inhibitors that bound to mutant IDH1 differently than the marketed inhibitor Ivosidenib, for which we have determined the x-ray...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39251618
DOI: 10.1038/s41467-024-51692-0
PMCID: PMC11385386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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