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Article

EphB4 forward signalling mediates angiogenesis caused by CCM3/PDCD10-ablation.

Journal of cellular and molecular medicine - 1 Sept 2017

You Chao, Zhao Kai, Dammann Philipp, Keyvani Kathy, Kreitschmann-Andermahr Ilonka, Sure Ulrich, Zhu Yuan

Abstract excerpt

CCM3, also named as PDCD10, is a ubiquitous protein expressed in nearly all tissues and in various types of cells. It is essential for vascular development and post-natal vessel maturation. Loss-of-function mutation of CCM3 predisposes for the familial form of cerebral cavernous malformation (CCM). We have previously shown that knock-down of CCM3 stimulated endothelial angiogenesis via impairing DLL4-Notch...

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Source

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Identifiers

PMID: 28371279
DOI: 10.1111/jcmm.13105
PMCID: PMC5571521

Genes

DLL4
PDCD10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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