Article
The Influence of HIV on the Evolution of Mycobacterium tuberculosis.
Molecular biology and evolution - 1 Jul 2017
Koch Anastasia S, Brites Daniela, Stucki David, Evans Joanna C, Seldon Ronnett, Heekes Alexa, Mulder Nicola, Nicol Mark, Oni Tolu, Mizrahi Valerie, Warner Digby F, Parkhill Julian, Gagneux Sebastien, Martin Darren P, Wilkinson Robert J
Abstract excerpt
HIV significantly affects the immunological environment during tuberculosis coinfection, and therefore may influence the selective landscape upon which M. tuberculosis evolves. To test this hypothesis whole genome sequences were determined for 169 South African M. tuberculosis strains from HIV-1 coinfected and uninfected individuals and analyzed using two Bayesian codon-model based selection analysis approaches:...
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