Article
SNP by SNP by environment interaction network of alcoholism.
BMC systems biology - 14 Mar 2017
Zollanvari Amin, Alterovitz Gil
Abstract excerpt
BACKGROUND: Alcoholism has a strong genetic component. Twin studies have demonstrated the heritability of a large proportion of phenotypic variance of alcoholism ranging from 50-80%. The search for genetic variants associated with this complex behavior has epitomized sequence-based studies for nearly a decade. The limited success of genome-wide association studies (GWAS), possibly precipitated by the polygenic...
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