Article
Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems.
Alcoholism, clinical and experimental research - 1 Feb 2018
Salvatore Jessica E, Savage Jeanne E, Barr Peter, Wolen Aaron R, Aliev Fazil, Vuoksimaa Eero, Latvala Antti, Pulkkinen Lea, Rose Richard J, Kaprio Jaakko, Dick Danielle M
Abstract excerpt
BACKGROUND: Characterizing aggregate genetic risk for alcohol misuse and identifying variants involved in gene-by-environment (G × E) interaction effects has so far been a major challenge. We hypothesized that functional genomic information could be used to enhance detection of polygenic signal underlying alcohol misuse and to prioritize identification of single nucleotide polymorphisms (SNPs) most likely to...
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