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Article

The crossover conformational shift of the GTPase atlastin provides the energy driving ER fusion.

The Journal of cell biology - 1 May 2017

Winsor James, Hackney David D, Lee Tina H

Abstract excerpt

The homotypic fusion of endoplasmic reticulum membranes is catalyzed by the atlastin GTPase. The mechanism involves trans-dimerization between GTPase heads and a favorable crossover conformational shift, catalyzed by GTP hydrolysis, that converts the dimer from a "prefusion" to "postfusion" state. However, whether crossover formation actually energizes fusion remains unclear, as do the sequence of events...

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Identifiers

PMID: 28356327
DOI: 10.1083/jcb.201609071
PMCID: PMC5412568

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