Article
Membrane tethering by the atlastin GTPase depends on GTP hydrolysis but not on forming the cross-over configuration.
Molecular biology of the cell - 1 Dec 2014
Saini Simran G, Liu Chuang, Zhang Peijun, Lee Tina H
Abstract excerpt
The membrane-anchored atlastin GTPase couples nucleotide hydrolysis to the catalysis of homotypic membrane fusion to form a branched endoplasmic reticulum network. Trans dimerization between atlastins anchored in opposing membranes, accompanied by a cross-over conformational change, is thought to draw the membranes together for fusion. Previous studies on the conformational coupling of atlastin to its GTP...
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