Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of human and Drosophila atlastin GTPases.

Protein & cell - 1 Feb 2015

Wu Fuyun, Hu Xiaoyu, Bian Xin, Liu Xinqi, Hu Junjie

Abstract excerpt

Formation of the endoplasmic reticulum (ER) network requires homotypic membrane fusion, which involves a class of atlastin (ATL) GTPases. Purified Drosophila ATL is capable of mediating vesicle fusion in vitro, but such activity has not been reported for any other ATLs. Here, we determined the preliminary crystal structure of the cytosolic segment of Drosophila ATL in a GDP-bound state. The structure reveals a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dimerization
Share to Drosophila
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to GTP-Binding Proteins

Share to GTP Phosphohydrolases

Share to Guanosine Diphosphate

Share to Protein Structure, Secondary

Source

Open in PubMed Open full text

Identifiers

PMID: 25407413
DOI: 10.1007/s13238-014-0118-0
PMCID: PMC4312763

Genes

ATL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of human and Drosophila atlastin GTPases.PMID 25407413Read ↗

Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes.Semantic proximity Read ↗

Reconstitution of human atlastin fusion activity reveals autoinhibition by the C terminus.Semantic proximity Read ↗

Cis and trans interactions between atlastin molecules during membrane fusion.Semantic proximity Read ↗

Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A.Semantic proximity Read ↗

Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.Semantic proximity Read ↗

The crossover conformational shift of the GTPase atlastin provides the energy driving ER fusion.Semantic proximity Read ↗

Membrane tethering by the atlastin GTPase depends on GTP hydrolysis but not on forming the cross-over configuration.Semantic proximity Read ↗

Sensory-Neuropathy-Causing Mutations in ATL3 Cause Aberrant ER Membrane Tethering.Semantic proximity Read ↗

Avl9 defines a family of GTPase-activating proteins that regulate diverse cell biological functionsSemantic proximity Read ↗

Efficient ER Fusion Requires a Dimerization and a C-Terminal Tail Mediated Membrane Anchoring of RHD3.Semantic proximity Read ↗

Sensory neuropathy-causing mutations in ATL3 cause aberrant ER membrane tetheringSemantic proximity Read ↗

A disease causing ATLASTIN 3 mutation affects multiple endoplasmic reticulum-related pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.