Article
Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice.
Cell reports - 28 Mar 2017
Yang Annie S P, O'Neill Matthew T, Jennison Charlie, Lopaticki Sash, Allison Cody C, Armistead Jennifer S, Erickson Sara M, Rogers Kelly L, Ellisdon Andrew M, Whisstock James C, Tweedell Rebecca E, Dinglasan Rhoel R, Douglas Donna N, Kneteman Norman M, Boddey Justin A
Abstract excerpt
Malaria sporozoites are deposited into the skin by mosquitoes and infect hepatocytes. The molecular basis of how Plasmodium falciparum sporozoites migrate through host cells is poorly understood, and direct evidence of its importance in vivo is lacking. Here, we generated traversal-deficient sporozoites by genetic disruption of sporozoite microneme protein essential for cell traversal (PfSPECT) or perforin-like...
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