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Liver invasion by malarial parasites - how do malarial parasites break through the host barrier?

4 Nov 2004

Abstract excerpt

Malarial transmission to the human host is established by sporozoite infection of the liver. Sporozoites are released from the mosquito salivary glands and carried by the blood flow to the liver sinusoid. In the sinusoid, sporozoites leave the blood circulation by crossing the sinusoidal cell layer to infect hepatocytes, the site for their development into the erythrocyte-invasive forms. Traversal of the...

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PMID: 15527492
DOI: 10.1111/j.1462-5822.2004.00474.x

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