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Article

Type III-A CRISPR immunity promotes mutagenesis of staphylococci.

Nature - 1 Apr 2021

Mo Charlie Y, Mathai Jacob, Rostøl Jakob T, Varble Andrew, Banh Dalton V, Marraffini Luciano A

Abstract excerpt

Horizontal gene transfer and mutation are the two major drivers of microbial evolution that enable bacteria to adapt to fluctuating environmental stressors1. Clustered, regularly interspaced, short palindromic repeats (CRISPR) systems use RNA-guided nucleases to direct sequence-specific destruction of the genomes of mobile genetic elements that mediate horizontal gene transfer, such as conjugative plasmids2 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33828299
DOI: 10.1038/s41586-021-03440-3
PMCID: PMC8820005

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