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Article

Influence of MTHFR Genetic Background on p16 and MGMT Methylation in Oral Squamous Cell Cancer.

International journal of molecular sciences - 29 Mar 2017

Ferlazzo Nadia, Currò Monica, Zinellu Angelo, Caccamo Daniela, Isola Gaetano, Ventura Valeria, Carru Ciriaco, Matarese Giovanni, Ientile Riccardo

Abstract excerpt

Genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) enzyme may influence DNA methylation. Alterations in DNA methylation patterns of genes involved in the regulation of the cell cycle, DNA repair, cell adherence and metastasis process are known to contribute to cancer development. In this study, the influence of the MTHFR C677T and A1298C gene polymorphisms on global DNA methylation and...

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Topics

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Share to Carcinoma, Squamous Cell
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Modification Methylases

Share to DNA Repair Enzymes

Share to Genes, p16

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Mouth Neoplasms

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28353639
DOI: 10.3390/ijms18040724
PMCID: PMC5412310

Genes

MGMT
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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