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Article

ZnT8 Arg325Trp polymorphism influences zinc transporter expression and cytokine production in PBMCs from patients with diabetes.

Diabetes research and clinical practice - 1 Oct 2018

Giacconi R, Malavolta M, Chiodi L, Boccoli G, Costarelli L, Bonfigli A R, Galeazzi R, Piacenza F, Basso A, Gasparini N, Nisi L, Testa R, Provinciali M

Abstract excerpt

AIMS: ZnT8 Arg325Trp polymorphism has been associated with type 2 diabetes (T2DM) susceptibility. The Arg-325 risk variant shows accelerated zinc (Zn) transport kinetic and reduced glucose-stimulated insulin secretion in pancreatic cells. However, it remains unexplored the role of Znt8 polymorphism in the regulation of Zn homeostasis and inflammatory response in peripheral blood mononuclear cells (PBMCs) from...

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PMID: 30142362
DOI: 10.1016/j.diabres.2018.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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