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Article

Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study.

Pharmacogenomics - 1 Apr 2017

Chaudhry Mamoonah, Alessandrini Marco, Rademan Jacobus, Dodgen Tyren M, Steffens Francois E, van Zyl Danie G, Gaedigk Andrea, Pepper Michael S

Abstract excerpt

AIM: Therapy with low-dose amitriptyline is commonly used to treat painful diabetic peripheral neuropathy. There is a knowledge gap, however, regarding the role of variable CYP2D6-mediated drug metabolism and side effects (SEs). We aimed to generate pilot data to demonstrate that SEs are more frequent in patients with variant CYP2D6 alleles. METHOD: To that end, 31 randomly recruited participants were treated...

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Identifiers

PMID: 28350251
DOI: 10.2217/pgs-2016-0185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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