Article

Evaluating the Clinical Impact of CYP2C19 and CYP2D6 on Amitriptyline Outcomes in a Real-World Chronic Pain Cohort

2026-06-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Amitriptyline is widely prescribed for chronic pain, yet treatment response and tolerability vary substantially. Genetic variation in CYP2C19 and CYP2D6 influences amitriptyline metabolism, but evidence linking pharmacogene status to clinical outcomes in chronic pain populations remains limited. Importantly, amitriptyline is typically prescribed at lower doses for chronic pa...

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Literature Corpus work: 779ed05b-5af0-5094-9fbf-acd0d0d68660
DOI: 10.64898/2026.05.28.26354228

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