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Article

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure.

Nature communications - 28 Mar 2017

Bluett Rebecca J, Báldi Rita, Haymer Andre, Gaulden Andrew D, Hartley Nolan D, Parrish Walker P, Baechle Jordan, Marcus David J, Mardam-Bey Ramzi, Shonesy Brian C, Uddin Md Jashim, Marnett Lawrence J, Mackie Ken, Colbran Roger J, Winder Danny G, Patel Sachin

Abstract excerpt

Stress is a ubiquitous risk factor for the exacerbation and development of affective disorders including major depression and posttraumatic stress disorder. Understanding the neurobiological mechanisms conferring resilience to the adverse consequences of stress could have broad implications for the treatment and prevention of mood and anxiety disorders. We utilize laboratory mice and their innate inter-individual...

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Identifiers

PMID: 28348378
DOI: 10.1038/ncomms14782
PMCID: PMC5379055

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