Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the application of sildenafil for high-fat diet-induced erectile dysfunction based on interleukin-18-mediated NLRP3/Caspase-1 signaling pathway

1 Aug 2023

Abstract excerpt

Abstract Background Inflammation is a key risk factor for heart disease and has also been linked to erectile dysfunction (ED). Sildenafil is a phosphodiesterase type 5 inhibitor with a strong antioxidant effect. Interleukin (IL)-18 is a proinflammatory factor. Excessive production and release of IL-18 disrupt the balance between IL-18 and IL-18 binding proteins in certain inflammatory diseases, leading to the...

Topics

Join the communities discussing this publication.

Inflammasome and immune disorders
Phosphodiesterase function and regulation
Sexual function and dysfunction studies

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37636019
DOI: 10.1093/sexmed/qfad044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the application of sildenafil for high-fat diet-induced erectile dysfunction based on interleukin-18-mediated NLRP3/Caspase-1 signaling pathwayPMID 37636019Read ↗

Galangin Resolves Cardiometabolic Disorders Through Modulation of AdipoR1/COX-2/ NF-κB Expressions in High-Fat Diet Fed RatsSemantic proximity Read ↗

Nesfatin-1 regulates the phenotype transition of cavernous smooth muscle cells by activating PI3K/AKT/mTOR signaling pathway to improve diabetic erectile dysfunction.Semantic proximity Read ↗

IL-18BP Therapy Ameliorates Reproductive and Metabolic Phenotypes in a PCOS Mouse Model by Relieving Inflammation, Fibrosis and Endoplasmic Reticulum Stress.Semantic proximity Read ↗

The Role of Sex in Atherosclerotic Inflammation and Lipid-Handling DysfunctionSemantic proximity Read ↗

Obesity or Overweight, a Chronic Inflammatory Status in Male Reproductive System, Leads to Mice and Human SubfertilitySemantic proximity Read ↗

Neuroinflammatory basis of metabolic syndromeSemantic proximity Read ↗

Hexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype switch and inflammasome activation.Semantic proximity Read ↗

International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions.Semantic proximity Read ↗

LncRNA MALAT1 Promotes STAT3-Mediated Endothelial Inflammation by Counteracting the Function of miR-590.Semantic proximity Read ↗

Medin-Induced Pro-inflammatory and Prothrombotic Activation of Coronary Artery Endothelial Cells: A Potential Novel Mediator Linking Aging and AtherosclerosisSemantic proximity Read ↗

Non-Coding RNAs: New Dawn for Diabetes Mellitus Induced Erectile DysfunctionSemantic proximity Read ↗

Ameliorating immune-dependent inflammation and apoptosis by targeting TLR4/MYD88/NF-κB pathway by celastrol mitigates the diabetic reproductive dysfunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.