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Article

Association Between Childhood-Onset Epilepsy and Amyloid Burden 5 Decades Later.

JAMA neurology - 1 May 2017

Joutsa Juho, Rinne Juha O, Hermann Bruce, Karrasch Mira, Anttinen Anu, Shinnar Shlomo, Sillanpää Matti

Abstract excerpt

Importance: The effect of childhood epilepsy on later-life cognitive and brain health is an unclear and little-explored issue. Objective: To determine whether adults with a history of childhood-onset epilepsy exhibit increased brain amyloid accumulation, possibly predisposing to accelerated cognitive impairment or even frank cognitive disorders in later life. Design, Setting, and Participants: Forty-one adults...

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Source

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Identifiers

PMID: 28346588
DOI: 10.1001/jamaneurol.2016.6091
PMCID: PMC5822199

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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