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Article

Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF-IRF4 transcription factor complex.

Nature immunology - 1 May 2017

Iwata Arifumi, Durai Vivek, Tussiwand Roxane, Briseño Carlos G, Wu Xiaodi, Grajales-Reyes Gary E, Egawa Takeshi, Murphy Theresa L, Murphy Kenneth M

Abstract excerpt

Variable strengths of signaling via the T cell antigen receptor (TCR) can produce divergent outcomes, but the mechanism of this remains obscure. The abundance of the transcription factor IRF4 increases with TCR signal strength, but how this would induce distinct types of responses is unclear. We compared the expression of genes in the TH2 subset of helper T cells to enhancer occupancy by the BATF-IRF4...

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Source

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Identifiers

PMID: 28346410
DOI: 10.1038/ni.3714
PMCID: PMC5401770

Genes

BATF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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