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Article

Modeling the phenotype of spinal muscular atrophy by the direct conversion of human fibroblasts to motor neurons.

Oncotarget - 14 Feb 2017

Zhang Qi-Jie, Li Jin-Jing, Lin Xiang, Lu Ying-Qian, Guo Xin-Xin, Dong En-Lin, Zhao Miao, He Jin, Wang Ning, Chen Wan-Jin

Abstract excerpt

Spinal muscular atrophy (SMA) is a lethal autosomal recessive neurological disease characterized by selective degeneration of motor neurons in the spinal cord. In recent years, the development of cellular reprogramming technology has provided an alternative and effective method for obtaining patient-specific neurons in vitro. In the present study, we applied this technology to the field of SMA to acquire...

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Identifiers

PMID: 28099929
DOI: 10.18632/oncotarget.14641
PMCID: PMC5355236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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