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Article

Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS.

Experimental & molecular medicine - 9 Dec 2016

Park Ju-Hwang, Park Hang-Soo, Hong Sunghoi, Kang Seongman

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disease characterized by the loss of motor neurons in the spinal cord and brain. Mutations in Cu/Zn superoxide dismutase 1 (SOD1) are known to induce ALS. Although many research models have been developed, the exact pathological mechanism of ALS remains unknown. The recently developed induced pluripotent stem (iPS) cell technology...

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Identifiers

PMID: 27932790
DOI: 10.1038/emm.2016.113
PMCID: PMC5192071

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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