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Whole genome sequencing of unusual Hepatitis C virus subtypes and drug resistance analysis during direct-acting antiviral therapy in India.

Diagnostic microbiology and infectious disease - 1 Dec 2026

Tomar Shilpa, Gangopadhayya Abhranil, Barman Bhupen, Ghuge Onkar, Korra Bhanu Teja, Bastin Ciyona, Lamare Baiahunlang, Ramdasi Ashwini, Lyngdoh Valarie W, Lole Kavita S, Kaur Harpreet

Abstract excerpt

INTRODUCTION AND OBJECTIVES: Pangenotypic direct-acting antivirals (DAA) are effective against highly prevalent Hepatitis C virus (HCV) subtypes, but have been clinically validated almost exclusively in high-income countries. Unusual HCV subtypes may carry natural polymorphisms, potentially impacting DAA susceptibility. We conducted full-genome characterization and resistance analysis of unusual HCV subtypes in...

Read the complete abstract on PubMed

Topics

Humans
Antiviral Agents
Hepacivirus
Drug Resistance, Viral
Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Whole Genome Sequencing

India

Phylogeny

Genome, Viral

Prospective Studies

Hepatitis C

Viral Nonstructural Proteins

Female

RNA, Viral

Viral Load

Middle Aged

Adult

Mutation

Source

Identifiers

PMID: 42600204
DOI: 10.1016/j.diagmicrobio.2026.117610

Provenance

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