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Article

Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms.

Developmental biology - 15 May 2017

Lewis Tylor R, Kundinger Sean R, Pavlovich Amira L, Bostrom Jonathan R, Link Brian A, Besharse Joseph C

Abstract excerpt

Zebrafish morphants of osm-3/kif17, a kinesin-2 family member and intraflagellar transport motor, have photoreceptor outer segments that are dramatically reduced in number and size. However, two genetic mutant lines, osm-3/kif17sa0119 and osm-3/kif17sa18340, reportedly lack any observable morphological outer segment defects. In this work, we use TALENs to generate an independent allele, osm-3/kif17mw405, and show...

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Identifiers

PMID: 28341548
DOI: 10.1016/j.ydbio.2017.03.019
PMCID: PMC5558849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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