Article
Kinesin-2 family in vertebrate ciliogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2012
Zhao Chengtian, Omori Yoshihiro, Brodowska Katarzyna, Kovach Peter, Malicki Jarema
Abstract excerpt
The differentiation of cilia is mediated by kinesin-driven transport. As the function of kinesins in vertebrate ciliogenesis is poorly characterized, we decided to determine the role of kinesin-2 family motors--heterotrimeric kinesin-II and the homodimeric Kif17 kinesin--in zebrafish cilia. We report that kif17 is largely dispensable for ciliogenesis; kif17 homozygous mutant animals are viable and display subtle...
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