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Article

Kinesin-2 family in vertebrate ciliogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2012

Zhao Chengtian, Omori Yoshihiro, Brodowska Katarzyna, Kovach Peter, Malicki Jarema

Abstract excerpt

The differentiation of cilia is mediated by kinesin-driven transport. As the function of kinesins in vertebrate ciliogenesis is poorly characterized, we decided to determine the role of kinesin-2 family motors--heterotrimeric kinesin-II and the homodimeric Kif17 kinesin--in zebrafish cilia. We report that kif17 is largely dispensable for ciliogenesis; kif17 homozygous mutant animals are viable and display subtle...

Topics

Animals
Base Sequence
Cilia
DNA Primers
Homozygote
Immunohistochemistry
Kinesins
Mutation
Polymerase Chain Reaction
Zebrafish

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PMID: 22308397
DOI: 10.1073/pnas.1116035109
PMCID: PMC3289367

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