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Regulation of intestinal myofibroblasts by KRas-mutated colorectal cancer cells through heparin-binding epidermal growth factor-like growth factor.

Oncology reports - 1 May 2017

Kawasaki Hideyoshi, Saotome Takuya, Usui Tatsuya, Ohama Takashi, Sato Koichi

Abstract excerpt

In colorectal cancer, gain-of-function mutations in KRas play a critical role in malignant transformation. Tumor growth in colorectal cancer is known to be promoted by the intestinal myofibroblasts (IMFs) that localize adjacent to the cancer cells, but the mechanisms of interaction between KRas-mutated cancer cells and the myofibroblasts remain unclear. Here, we investigated the effects of KRas-mutated cells on...

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PMID: 28339087
DOI: 10.3892/or.2017.5520

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EGF

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