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Article

MicroRNA filters Hox temporal transcription noise to confer boundary formation in the spinal cord.

Nature communications - 24 Mar 2017

Li Chung-Jung, Hong Tian, Tung Ying-Tsen, Yen Ya-Ping, Hsu Ho-Chiang, Lu Ya-Lin, Chang Mien, Nie Qing, Chen Jun-An

Abstract excerpt

The initial rostrocaudal patterning of the neural tube leads to differential expression of Hox genes that contribute to the specification of motor neuron (MN) subtype identity. Although several 3' Hox mRNAs are expressed in progenitors in a noisy manner, these Hox proteins are not expressed in the progenitors and only become detectable in postmitotic MNs. MicroRNA biogenesis impairment leads to precocious...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28337978
DOI: 10.1038/ncomms14685
PMCID: PMC5376671

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