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Article

MicroRNA-dependent regulation of Hox gene expression sculpts fine-grain morphological patterns in a Drosophila appendage.

Development (Cambridge, England) - 16 Oct 2018

Kaschula Richard, Pinho Sofia, Alonso Claudio R

Abstract excerpt

Disruptions of normal Hox gene expression can lead to severe morphological defects, revealing a link between the regulation of Hox expression and pattern formation. Here, we explore these links, focusing on the impact of microRNA regulation on the expression of the Drosophila Hox gene Ultrabithorax (Ubx) during haltere development. Through a combination of bioinformatic and transcriptomic analyses, we identify...

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PMID: 30143542
DOI: 10.1242/dev.161133
PMCID: PMC6215401

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