Article
Global control of motor neuron topography mediated by the repressive actions of a single hox gene.
Neuron - 9 Sept 2010
Jung Heekyung, Lacombe Julie, Mazzoni Esteban O, Liem Karel F, Grinstein Jonathan, Mahony Shaun, Mukhopadhyay Debnath, Gifford David K, Young Richard A, Anderson Kathryn V, Wichterle Hynek, Dasen Jeremy S
Abstract excerpt
In the developing spinal cord, regional and combinatorial activities of Hox transcription factors are critical in controlling motor neuron fates along the rostrocaudal axis, exemplified by the precise pattern of limb innervation by more than fifty Hox-dependent motor pools. The mechanisms by which motor neuron diversity is constrained to limb levels are, however, not well understood. We show that a single Hox...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.