Antimutagenic effects of chemicals on mutagenesis resulting from excision of a transposon in Salmonella typhimurium.

Abstract excerpt

We have found that a temperature-sensitive mutation in the polA gene of Salmonella typhimurium strain LT2 causes precise excision of transposon Tn10 to occur at significantly increased frequencies in cells incubated at the restrictive temperature. In our experiments, precise excision from a site in the tryptophan operon was measured by determining the frequency of reversion of the auxotrophic trp1014::Tn10 polA7...

Topics

• Bacterial Proteins
• DNA Polymerase I
• DNA Repair
• DNA Transposable Elements
• Mutagens
• Mutation
• Salmonella typhimurium