Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of secretion and enzymatic activity of lipoprotein lipase by C-mannosylation.

Biochemical and biophysical research communications - 29 Apr 2017

Okamoto Sawako, Murano Takeyoshi, Suzuki Takehiro, Uematsu Shiho, Niwa Yuki, Sasazawa Yukiko, Dohmae Naoshi, Bujo Hideaki, Simizu Siro

Abstract excerpt

Lipoprotein lipase (LPL) is a crucial enzyme in lipid metabolism and transport, and its enzymatic deficiency causes metabolic disorders, such as hypertriglyceridemia. LPL has one predicted C-mannosylation site at Trp417. In this study, we demonstrated that LPL is C-mannosylated at Trp417 by mass spectrometry. Furthermore, by using wild-type and a C-mannosylation-defective mutant of LPL-overexpressing cell lines,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Library
Share to Glycosylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to Lipoprotein Lipase

Share to Mannose

Share to Protein Processing, Post-Translational

Share to Recombinant Fusion Proteins

Share to Tryptophan

Source

Identifiers

PMID: 28327359
DOI: 10.1016/j.bbrc.2017.03.085

Genes

LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of secretion and enzymatic activity of lipoprotein lipase by C-mannosylation.PMID 28327359Read ↗

Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme.Semantic proximity Read ↗

The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes.Semantic proximity Read ↗

DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3.Semantic proximity Read ↗

Mutational analysis of human lipoprotein lipase by carboxy-terminal truncation.Semantic proximity Read ↗

The Role of Monoacylglycerol Lipase (MAGL) in the Cancer ProgressSemantic proximity Read ↗

Site-directed mutagenesis studies of the aromatic residues at the active site of a lipase from Malassezia globosa.Semantic proximity Read ↗

Gradually glycosylated protein C mutants (Arg178Gln and Cys331Arg) are degraded by proteasome after mannose trimming.Semantic proximity Read ↗

Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia.Semantic proximity Read ↗

Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum.Semantic proximity Read ↗

Intracellular transport of human lysosomal alpha-mannosidase and alpha-mannosidosis-related mutants.Semantic proximity Read ↗

A newly identified lipoprotein lipase (LPL) gene mutation (F270L) in a Japanese patient with familial LPL deficiency.Semantic proximity Read ↗

L273S missense substitution in human lysosomal acid lipase creates a new N-glycosylation site.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.