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Article

Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP.

Biochemical and biophysical research communications - 6 May 2017

Kruglov Emma, Ananthanarayanan Meenakshisundaram, Sousa Pedro, Weerachayaphorn Jittima, Guerra Mateus T, Nathanson Michael H

Abstract excerpt

The type 2 inositol 1,4,5-trisphosphate receptor (IP3R2) is the principal intracellular Ca2+ release channel in hepatocytes, and so is important for bile secretion and other functions. IP3R2 activity is regulated in part by post-translational modifications but little is known about transcriptional regulation of its expression. We found that both IP3R2 mRNA and protein levels in liver were increased during...

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PMID: 28327356
DOI: 10.1016/j.bbrc.2017.03.086
PMCID: PMC5421629

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