Article

Liver–Intestine CREBH Regulates Systemic Glucose and Lipid Metabolism

2018-03-28

Abstract excerpt

The cyclic AMP-responsive element-binding protein H (CREBH, encoded by CREB3L3) is a membrane-bound transcriptional factor that primarily localizes in the liver and small intestine. CREBH governs triglyceride metabolism in the liver, which mediates the changes in gene expression governing fatty acid oxidation, ketogenesis, and apolipoproteins upregulating LPL activity. A deficiency of CREBH in mice leads to severe...

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Literature Corpus work: 3e7cf9c3-be81-5515-b9ab-1dfd4886682f
DOI: 10.20944/preprints201803.0234.v1

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