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TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours

21 Mar 2017

Abstract excerpt

BACKGROUND: TRIM8 plays a key role in controlling the p53 molecular switch that sustains the transcriptional activation of cell cycle arrest genes and response to chemotherapeutic drugs. The mechanisms that regulate TRIM8, especially in cancers like clear cell Renal Cell Carcinoma (ccRCC) and colorectal cancer (CRC) where it is low expressed, are still unknown. However, recent studies suggest the potential...

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PMID: 28327152
DOI: 10.1186/s12943-017-0634-7

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