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Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer?

10 Apr 2019

Abstract excerpt

Chemosensitivity is a crucial feature for all tumours so that they can be successfully treated, but the huge heterogeneity of these diseases, to be intended both inter- and intra-tumour, makes it a hard-to-win battle. Indeed, this genotypic and phenotypic variety, together with the adaptability of tumours, results in a plethora of chemoresistance acquisition mechanisms strongly affecting the effectiveness of...

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PMID: 30974870
DOI: 10.3390/ijms20071776

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